- Title
- Evolving GRN-inspired in vitro oscillatory systems
- Creator
- Dinh, Quang Huy; Aubert, Nathanael; Noman, Nasimul; Iba, Hitoshi; Rondelez, Yannic
- Relation
- Evolutionary Computation in Gene Regulatory Network Research p. 269-297
- Relation
- Bioinformatics: Computational Techniques and Engineering
- Publisher Link
- http://dx.doi.org/10.1002/9781119079453.ch11
- Publisher
- John Wiley & Sons
- Resource Type
- book chapter
- Date
- 2016
- Description
- This chapter addresses the issue of generating target behaviors in in vitro chemical systems that utilizes the notions of gene regulatory networks (GRN). It presents the working principle of evolving reaction network (ERNe). ERNe was demonstrated by evolving credible biochemical answers to challenging autonomous molecular problems: in vitro batch oscillatory networks that match specific oscillation shapes. The chapter describes the Polymerase/Exonuclease/Nickase Dynamic Network Assembly toolbox (PEN DNA toolbox), how it is modeled based on biochemistry, and its components. The PEN DNA toolbox was inspired by GRNs. In such networks, regulation comes in two flavors: activatory or inhibitory, respectively increasing and decreasing the expression of a targeted gene. One of their goals was to reproduce such mechanisms while removing the complexity of using RNA and proteins in the network. The chapter discusses the design of genetic or chemical circuits by using evolutionary computation (EC) techniques.
- Subject
- evolutionary computation; evolving reaction network; gene regulatory networks; in vitro oscillatory systems; PEN DNA toolbox
- Identifier
- http://hdl.handle.net/1959.13/1323181
- Identifier
- uon:24749
- Identifier
- ISBN:9781118911518
- Language
- eng
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